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Publications

Our mathematical models, algorithms and bioinformatic evaluations are reflected in scientific publications. Below you will find the complete publication list of BioControl Jena GmbH.

S. Schäuble, D. Albrecht-Eckardt, G. Panagiotou
FungiNetDB: A Uniform (pre-)processing Platform for Fungal Expression Data.
In: microLife (2026).
doi:/10.1093/femsml/uqag012
T. Hoffmann, U. Teichgräber, B. Lassen-Schmidt, D. Renz, L. B. Brüheim, T. Weise, M. Krämer, J. Böttcher, F. Güttler, G. Wolf, A. Pfeil
AI-based HRCT quantification reveals DLCO and TLC as key determinants of ILD severity in connective tissue diseases.
In: RMD Open (2025).
doi:/10.1136/rmdopen-2025-005963
E. Garbe, S. Schäuble, B. Böttcher, R. Jesse, D. Driesch, L. van Wilijck, O. Elshafee, T. B. Schille, B. Hube, G. Panagiotou, S. Vylkova
A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism in Candida albicans.
In: mSystems (2025).
doi:/10.1128/msystems.00226-25
T. Hoffmann, U. Teichgräber, L. B. Brüheim, B. Lassen-Schmidt, D. Renz, T. Weise, M. Krämer, P. Oelzner, J. Böttcher, F. Güttler, G. Wolf, A. Pfeil
The association of symptoms, pulmonary function test and computed tomography in interstitial lung disease at the onset of connective tissue disease: an observational study with artificial intelligence analysis of high-resolution computed tomography
In: Rheumatology International (2025).
doi:/10.1007/s00296-025-05934-z
A. Garcia Lopez, D. Albrecht-Eckardt, G. Panagiotou, S. Schäuble
FungiFun3: systemic gene set enrichment analysis for fungal species.
In: Bioinformatics (2024).
doi:/10.1093/bioinformatics/btae620
T. Hoffmann, U. Teichgräber, M. Förster, P. Oelzner, C. Kroegel, D. Renz, T. Weise, J. Böttcher, P. C. Schulze, G. Wolf, M. Franz, A. Pfeil
Correlation of high-resolution computed tomography and immunological bronchoalveolar lavage in interstitial lung disease at the onset of inflammatory rheumatic diseases: implications for diagnosis and therapeutic strategies.
In: Arthritis Res Ther (2024).
doi:/10.1186/s13075-024-03371-0
R. Hasseli, F. Hanses, M. Stecher, C. Specker, T. Weise, S. Borgmann, M. Hasselberger, B. Hertenstein, M. Hower, B. F. Hoyer, C. Koll, A. Krause, M. von Lilienfeld-Toal, H. Lorenz, U. Merle, S. M. Nunes de Miranda, M. W. Pletz, A. C. Regierer, J. G. Richter, S. Rieg, C. Roemmele, M. M. Ruethrich, T. Schmeiser, H. Schulze-Koops, A. Strangfeld, M. J.G.T. Vehreschild, F. Voit, R. E. Voll, J. J. Vehreschild, U. Müller-Ladner, A. Pfeil
The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population – A comparison of two German registries.
In: Frontiers in Medicine (2024).
doi:/10.3389/fmed.2024.1332716
A. Pfeil, P. Klemm, A. J. Hueber, T. Hoffmann, T. Weise, P. Oelzner, S. Knop, U. Müller-Ladner, U. Lange, G. Wolf, G. Schett, D. Simon, A. Kleyer
Enhancing student understanding of rheumatic disease pathologies through augmented reality: findings from a multicentre trial.
In: Rheumatology (2023).
doi:/10.1093/rheumatology/kead508
P. Brandt, M. H. Mirhakkak, L. Wagner, D. Driesch, A. Möslinger, P. Fänder, S. Schäuble, G. Panagiotou, S. Vylkova
High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences.
In: Microbiol Spectr (2023).
doi:/10.1128/spectrum.00498-23
A. Pfeil, M. Heinz, T. Hoffmann, T. Weise, D. M. Renz, M. Franz, A. Malich, D. Driesch, P. Oelzner, G. Wolf, J. Böttcher
The relationship between structural analysis of the hand and clinical characteristics in psoriatic arthritis.
In: Scientific Reports (2022).
doi:/10.1038/s41598-022-23555-5
E. Garbe, F. Gerwien, D. Driesch, T. Müller, B. Böttcher, M. Gräler, S. Vylkova
Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation.
In: mSystems (2022).
doi:/10.1128/msystems.00539-22
L. Ringleben, T. Weise, H. T. T. Truong, L. H. Anh, M. Pfaff
Experimental and model-based characterisation of Bacillus spizizenii growth under different temperature, pH and salinity conditions prior to aquacultural wastewater treatment application.
In: Bacillus spizizenii (2022).
doi:/10.1016/j.bej.2022.108630
B. Böttcher, D. Driesch, T. Krüger, E. Garbe, F. Gerwien, O. Kniemeyer, A. A. Brakhage, S. Vylkova
Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms
In: Candida albicans (2022).
doi:/10.1038/s41522-022-00341-9
L. Malich, F. Gühne, T. Hoffmann, A. Malich, T. Weise, P. Oelzner, G. Wolf, M. Freesmeyer, A. Pfeil
Distribution patterns of arterial affection and the influence of glucocorticoids on 18F-fluorodeoxyglucose positron emission tomography/CT in patients with giant cell arteritis.
In: RMD Open (2022).
doi:/10.1136/rmdopen-2022-002464
T. E. Klassert, C. Zubiria-Barrera, R. Neubert, M. Stock, A. Schneegans, M. López, D. Driesch, G. Zakonsky, P. Gastmeier, H. Slevogt, R. Leistner
Comparative analysis of surface sanitization protocols on the bacterial community structures in the hospital environment.
In: Clinical Microbiology and Infection (2022).
doi:/10.1016/j.cmi.2022.02.032
T. E. Klassert, R. Leistner, C. Zubiria-Barrera, M. Stock, M. López, R. Neubert, D. Driesch, P. Gastmeier, H. Slevogt
Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study.
In: Microbiome (2021).
doi:/10.1186/s40168-021-01109-7
F. Padberg, T. Höper, S. Henkel, D. Driesch, A. Luch, S. Zellmer
Novel indirect co-culture of immortalised hepatocytes with monocyte derived macrophages is characterised by pro-inflammatory cytokine networks.
In: Toxicology in Vitro (2021).
doi:/10.1016/j.tiv.2021.105134
S. Hirschmann, A. Gómez-Mejia, U. Mäder, J. Karsunke, D. Driesch, M. Rohde, S. Häussler, G. Burchhardt, S. Hammerschmidt
The two-component system 09 regulates pneumococcal carbohydrate metabolism and capsule expression.
In: Microorganisms (2021).
doi:/10.3390/microorganisms9030468
T. E. Klassert, C. Zubiria-Barrera, S. Kankel, M. Stock, R. Neubert, F. Lorenzo-Diaz, N. Doehring, D. Driesch, D. Fischer, H. Slevogt
Early bacterial colonization and antibiotic resistance gene acquisition in newborns.
In: Front. Cell. Infect. Microbiol. (2020).
doi:/10.3389/fcimb.2020.00332
T. Weise, C. Grewe, M. Pfaff
Experimental and model-based analysis to optimize microalgal biomass productivity in a pilot-scale tubular photobioreactor.
In: Front. Bioeng. Biotechnol. (2020).
doi:/10.3389/fbioe.2020.00453
B. Böttcher, B. Hoffmann, E. Garbe, T. Weise, Z. Cseresnyés, P. Brandt, S. Dietrich, D. Driesch, M. T. Figge, S. Vylkova
The transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainability.
In: Front. Microbiol. (2020).
doi:/10.3389/fmicb.2020.00794
S. Maenz, O. Brinkmann, I. Hasenbein, C. Braun, E. Kunisch, V. Horbert, F. Gunnella, A. Sachse, S. Bischoff, H. Schubert, K. D. Jandt, J. Bossert, D. Driesch, R. W. Kinne, M. Bungartz
The old sheep: a convenient and suitable model for senile osteopenia.
In: Journal of Bone and Mineral Metabolism (2020).
doi:/10.1007/s00774-020-01098-x
S. Ruben, E. Garbe, S. Mogavero, D. Albrecht-Eckardt, D. Hellwig, A. Häder, T. Krüger, K. Gerth, I. D. Jacobsen, O. Elshafee, S. Brunke, K. Hünniger, O. Kniemeyer, A. A. Brakhage, J. Morschhäuser, B. Hube, S. Vylkova, O. Kurzai, R. Martin
Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans.
In: mBio (2020).
doi:/10.1128/mBio.00206-20
T. Conrad, O. Kniemeyer, S. G. Henkel, T. Krüger, D. J. Mattern, V. Valiante, R. Guthke, I. D. Jacobsen, A. A. Brakhage, S. Vlaic, J. Linde
Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin.
In: BMC Systems Biology (2018).
doi:/10.1186/s12918-018-0620-8
T. E. Klassert, S. Goyal, M. Stock, D. Driesch, A. Hussain, L. C. Berrocal-Almanza, R. Myakala, G. Sumanlatha, V. Valluri, N. Ahmed, R. R. Schumann, C. Flores, H. Slevogt
AmpliSeq screening of genes encoding the C-type lectin receptors and their signaling components reveals a common variant in MASP1 associated with pulmonary tuberculosis in an Indian population.
In: Frontiers in Immunology (2018).
doi:http://dx.doi.org/10.3389/fimmu.2018.00242
R. Lehmann, M. M. Müller, T. E. Klassert, D. Driesch, M. Stock, A. Heinrich, T. Conrad, C. Moore, U. K. Schier, R. Guthke, H. Slevogt
Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells.
In: Mucosal Immunology (2018).
doi:http://dx.doi.org/10.1038/mi.2017.100
V. Horbert, M. Lange, T. Reuter, M. Hoffmann, S. Bischoff, J. Borowski, H. Schubert, D. Driesch, J. Mika, C. Hurschler, R. W. Kinne
Comparison of near-infrared spectroscopy with needle indentation and histology for the determination of cartilage thickness in the large animal model sheep.
In: Cartilage (2017).
doi:http://dx.doi.org/10.1177/1947603517731851
N. Amarsaikhan, D. Albrecht-Eckardt, C. Sasse, G. H. Braus, Z. B. Ogel, O. Kniemeyer
Proteomic profiling of the antifungal drug response of Aspergillus fumigatus to voriconazole.
In: International Journal of Medical Microbiology (2017).
doi:http://dx.doi.org/10.1016/j.ijmm.2017.07.011
M. M. Müller, R. Lehmann, T. E. Klassert, S. Reifenstein, T. Conrad, C. Moore, A. Kuhn, A. Behnert, R. Guthke, D. Driesch, H. Slevogt
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression.
In: Scientific Reports (2017).
doi:http://dx.doi.org/10.1038/s41598-017-00828-y
D. Tominski, J. Katchanov, D. Driesch, M. B. Daley, A. Liedtke, A. Schneider, H. Slevogt, K. Arastéh, H. Stocker
The late-presenting HIV-infected patient 30 years after the introduction of HIV testing: spectrum of opportunistic diseases and missed opportunities for early diagnosis.
In: HIV Medicine (2017).
doi:http://dx.doi.org/10.1111/hiv.12403
L. C. Berrocal-Almanza, S. Goyal, A. Hussain, T. E. Klassert, D. Driesch, Z. Grozdanovic, G. Sumanlatha, N. Ahmed, V. Valluri, M. L. Conrad, N. Dittrich, R. R. Schumann, B. Lala, H. Slevogt
S100A12 is up-regulated in pulmonary tuberculosis and predicts the extent of alveolar infiltration on chest radiography: an observational study.
In: Scientific Reports (2016).
doi:http://dx.doi.org/10.1038/srep31798
D. Hellwig, J. Voigt, M. Bouzani, J. Löffler, D. Albrecht-Eckardt, M. Weber, S. Brunke, R. Martin, O. Kurzai, K. Hünniger
Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a zinc depletion response.
In: Frontiers in Microbiology (2016).
doi:http://dx.doi.org/10.3389/fmicb.2016.00750
M. Böhringer, S. Pohlers, S. Schulze, D. Albrecht-Eckardt, J. Piegsa, M. Weber, R. Martin, K. Hünniger, J. Linde, R. Guthke, O. Kurzai
Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.
In: Cellular Microbiology (2016).
doi:http://dx.doi.org/10.1111/cmi.12566
A. Ghallab, G. Cellière, S. G. Henkel, D. Driesch, S. Hoehme, U. Hofmann, S. Zellmer, P. Godoy, A. Sachinidis, M. Blaszkewicz, R. Reif, R. Marchan, L. Kuepfer, D. Häussinger, D. Drasdo, R. Gebhardt, J. G. Hengstler
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.
In: Journal of Hepatology (2016).
doi:http://dx.doi.org/10.1016/j.jhep.2015.11.018
M. Bartl, M. Pfaff, A. Ghallab, D. Driesch, S. G. Henkel, J. G. Hengstler, S. Schuster, C. Kaleta, R. Gebhardt, S. Zellmer, P. Li
Optimality in the zonation of ammonia detoxification in rodent liver.
In: Archives of Toxicology (2015).
doi:http://dx.doi.org/10.1007/s00204-015-1596-4
I. Leonhardt, S. Spielberg, M. Weber, D. Albrecht-Eckardt, M. Bläss, R. Claus, D. Barz, K. Scherlach, C. Hertweck, J. Löffler, K. Hünniger, O. Kurzai
Farnesol - a quorum sensing molecule of Candida albicans modulates innate immunity.
In: Mycoses (2015).
doi:http://dx.doi.org/10.1111/myc.12361
Z. Grozdanovic, L. C. Berrocal Almanza, S. Goyal, A. Hussain, T. E. Klassert, D. Driesch, V. Tokaryeva, Y. Y. Löschmann, G. Sumanlatha, N. Ahmed, V. Valluri, R. R. Schumann, B. Lala, H. Slevogt
A novel reading scheme for assessing the extent of radiographic abnormalities and its association with disease severity in sputum smear-positive tuberculosis: an observational study in Hyderabad/India.
In: PLOS ONE (2015).
doi:http://dx.doi.org/10.1371/journal.pone.0138070
I. Leonhardt, S. Spielberg, M. Weber, D. Albrecht-Eckardt, M. Bläss, R. Claus, D. Barz, K. Scherlach, C. Hertweck, J. Löffler, K. Hünniger, O. Kurzai
The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity.
In: mBio (2015).
doi:http://dx.doi.org/10.1128/mBio.00143-15
S. Schulze, S. G. Henkel, D. Driesch, R. Guthke, J. Linde
Computational prediction of molecular pathogen-host interactions based on dual transcriptome data.
In: Frontiers in Microbiology (2015).
doi:http://dx.doi.org/10.3389/fmicb.2015.00065
F. Schliess, S. Hoehme, S. G. Henkel, A. Ghallab, D. Driesch, J. Böttger, R. Guthke, M. Pfaff, J. G. Hengstler, R. Gebhardt, D. Häussinger, D. Drasdo, S. Zellmer
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration.
In: Hepatology (2014).
doi:http://dx.doi.org/10.1002/hep.27136
S. G. Henkel, A. Ter Beek, S. Steinsiek, S. Stagge, K. Bettenbrock, M. J. Teixeira de Mattos, T. Sauter, O. Sawodny, M. Ederer
Basic regulatory principles of Escherichia coli's electron transport chain for varying oxygen conditions.
In: PLoS ONE (2014).
doi:http://dx.doi.org/10.1371/journal.pone.0107640
D. Woetzel, R. Huber, P. Kupfer, D. Pohlers, M. Pfaff, D. Driesch, T. Häupl, D. Koczan, P. Stiehl, R. Guthke, R. W. Kinne
Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation.
In: Arthritis Research & Therapy (2014).
doi:http://dx.doi.org/10.1186/ar4526
F. F. Stecker, J.-H. Schierz, T. Opfermann, D. Driesch, G. O. Hofmann, T. Winkens, M. Freesmeyer
Frühe dynamische PET/CT-Aufnahmen zur Diagnostik der chronischen Osteomyelitis und Fraktur der unteren Extremität - Pilotstudie.
In: Nuklearmedizin (2014).
doi:http://dx.doi.org/10.3413/Nukmed-0572-13-03
M. Böhringer, S. Schulze, J. Linde, D. Albrecht-Eckardt, R. Guthke, O. Kurzai
Transcriptional response of C2BBe1 intestinal epithelial cells to Candida albicans infection.
In: Mycoses (2013).
doi:http://dx.doi.org/10.1111/myc.12110
R. Martin, A. Haeder, K. Meinhardt, D. Albrecht-Eckardt, S. Brunke, K. Hünniger, B. Hube, J. Morschhäuser, O. Kurzai
Expression dynamics of core filamentation response genes in the hyper倾向 Candida albicans tup1Δ mutant.
In: Mycoses (2013).
doi:http://dx.doi.org/10.1111/myc.12109
J. Voigt, I. D. Jacobsen, M. Bouzani, J. Loeffler, D. Albrecht-Eckardt, O. Kurzai
Natural killer cells modulate the immune response in Candida-infections.
In: Candida (2013).
Archive material
A. Darr, T. Opfermann, T. Niksch, D. Driesch, R. J. Marlowe, M. Freesmeyer
Low-Activity 124I-PET/Low-Dose CT Versus 99mTc-Pertechnetate Planar Scintigraphy or 99mTc-Pertechnetate Single-Photon Emission Computed Tomography of the Thyroid: A Pilot Comparison.
In: Clinical Nuclear Medicine (2013).
doi:http://dx.doi.org/10.1097/RLU.0b013e3182a20d26
M. Weber, S. G. Henkel, S. Vlaic, R. Guthke, E. J. van Zoelen, D. Driesch
Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0.
In: BMC Systems Biology (2013).
doi:http://dx.doi.org/10.1186/1752-0509-7-1
T. Kaulfuss, J. Voigt, R. Martin, D. Driesch, O. Kurzai
Transcriptional dynamics of Candida albicans and human Natural Killer cells during interaction.
In: Candida albicans (2012).
Archive material
A. Lovas, A. Weidemann, D. Albrecht, L. Wiechert, D. Weih, F. Weih
p100 Deficiency Is Insufficient for Full Activation of the Alternative NF-kB Pathway: TNF Cooperates with p52-RelB in Target Gene Transcription.
In: PLoS ONE (2012).
doi:http://dx.doi.org/10.1371/journal.pone.0042741
D. Wartenberg, M. Vödisch, O. Kniemeyer, D. Albrecht-Eckardt, K. Scherlach, R. Winkler, M. Weide, A. A. Brakhage
Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans - The role of a putative dehydrin.
In: Journal of Proteomics (2012).
doi:http://dx.doi.org/10.1016/j.jprot.2012.05.023
S. Bruns, M. Seidler, D. Albrecht, S. Salvenmoser, N. Remme, A. A. Brakhage, C. Hertweck, O. Kniemeyer, F. M. C. Mueller
Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.
In: Proteomics (2010).
doi:http://dx.doi.org/10.1002/pmic.201000129
J. Teutschbein, D. Albrecht, M. Poetsch, R. Winkler, R. Guthke, A. A. Brakhage, O. Kniemeyer
Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic fungus Aspergillus fumigatus.
In: J Proteome Res (2010).
doi:http://dx.doi.org/10.1021/pr9010684
C. Heinze, R. Pilchowski, C. Melle, N. Escher, D. Driesch, H. Wunderlich, K. Junker
Protein profiling of metastatic and non-metastatic renal cell carcinomas.
In: Cellular Oncology (2010).
Archive material
D. Albrecht, O. Kniemeyer, A. A. Brakhage, R. Guthke
OmniFung: Data Warehouse for integrating -omics data of human-pathogenic fungi.
In: Infection (2009).
Archive material
M. Voedisch, D. Albrecht, F. Leßing, A.D. Schmidt, R. Winkler, R. Guthke, A.A. Brakhage, O. Kniemeyer
Two-dimensional proteome reference maps for the human-pathogenic filamentous fungus Aspergillus fumigatus.
In: Proteomics (2009).
doi:http://dx.doi.org/10.1002/pmic.200800394
A. Lovas, D. Radke, D. Albrecht, Z.B. Yilmaz, U. Moeller, A.J.R. Habenicht, F. Weih
Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts.
In: BMC Genomics (2008).
doi:http://dx.doi.org/10.1186/1471-2164-9-606
D. Albrecht, R. Guthke, O. Kniemeyer, A.A. Brakhage
Systems biology of human-pathogenic fungi.
In: IGI Global (2008).
Archive material
D. Albrecht, O. Kniemeyer, A.A. Brakhage, R. Guthke
Normalisation of 2D DIGE Data - On the Way to a Standard Operating Procedure.
In: BIRD08, Schriftenreihe Informatik (2008).
Archive material
N. Escher, M. Kaatz, C. Melle, C. Hipler, M. Ziemer, D. Driesch, U. Wollina, F. von Eggeling
Posttranslational modifications of transthyretin are serum markers in patients with mycosis fungoides.
In: Neoplasia (2007).
doi:http://dx.doi.org/10.1593/neo.06805
J. Sanjmyatav, D. Driesch, C. Schwaenen, S. Wessendorf, J. Schubert, K. Junker
Genome-wide copy number profiling and TNM staging of renal cell tumors.
In: BJU International (2007).
Archive material
K. Junker, J. Mueller, R. Pilchowski, C. Melle, F. von Eggeling, D. Driesch, J. Schubert
Identification of serum amyloid alpha and transthyretin as biomarkers for clear cell renal cell carcinomas.
In: European Urology Supplements (2007).
doi:http://dx.doi.org/10.1016/S1569-9056(07)60446-1
O. Reichelt, J. Müller, F. von Eggeling, D. Driesch, H. Wunderlich, J. Schubert, H.-J. Gröne, G. Stein, U. Ott, K. Junker
Prediction of renal allograft rejection by urinary protein analysis using ProteinChip Arrays (surface-enhanced laser desorption/ionization time-of-flight mass spectrometry).
In: Urology (2006).
doi:http://dx.doi.org/10.1016/j.urology.2005.09.038
N. Escher, B. Spies-Weisshart, M. Kaatz, C. Melle, A. Bleul, D. Driesch, Uwe Wollina, F. von Eggeling
Identification of HNP3 as a tumour marker in CD4+ and CD4- lymphocytes of patients with cutaneous T-cell lymphoma.
In: European Journal of Cancer (2006).
doi:http://dx.doi.org/10.1016/j.ejca.2005.07.033
R. Guthke, W. Schmidt-Heck, G. Pless, R. Gebhardt, M. Pfaff, J.C. Gerlach, K. Zeilinger
Dynamic Model of Amino Acid and Carbohydrate Metabolism in Primary Human Liver Cells.
In: Lect Notes Bioinformatics (2006).
doi:http://dx.doi.org/10.1007/11946465_13
R. Guthke, K. Zeilinger, S. Sickinger, W. Schmidt-Heck, H. Buentemeyer, K. Iding, J. Lehmann, M. Pfaff, G. Pless, J.C. Gerlach
Dynamics of Amino Acid Metabolism of Primary Human Liver Cells in 3D Bioreactors.
In: Bioprocess Biosyst Eng (2006).
doi:http://dx.doi.org/10.1007/s00449-005-0040-1
A. Busch, S. Michel, C. Hoppe, D. Driesch, U. Claussen, F. von Eggeling
Proteome Analysis of Maternal Serum Samples for Trisomy 21 Pregnancies using ProteinChip Arrays and Bioinformatics.
In: Journal of Histochemistry & Cytochemistry (2005).
doi:http://dx.doi.org/10.1369/jhc.4B6377.2005
R. Guthke, W. Schmidt-Heck, M. Pfaff, S. Toepfer, D. Driesch, K. Iding, H. Buentemeyer, J. Lehmann, K. Zeilinger, G. Pless, P. Neuhaus, J. Gerlach
Network Based Analysis of the System Dynamics of a Bioartificial 3D Human Liver Cell Bioreactor for Extracorporeal Liver Support.
In: The International Journal of Artificial Organs (2005).
Archive material
K. Junker, J. Gneist, C. Melle, D. Driesch, J. Schubert, U. Claussen, F. von Eggeling
Identification of Protein Pattern in Kidney Cancer using ProteinChip® Arrays and Bioinformatics.
In: International Journal of Molecular Medicine (2005).
Archive material
J. Mueller, F. von Eggeling, D. Driesch, J. Schubert, C. Melle, K. Junker
ProteinChip Technology Reveals Distinctive Protein Expression Profiles in the Urine of Bladder Cancer Patients.
In: European Urology (2005).
doi:http://dx.doi.org/10.1016/j.eururo.2005.02.016
M. Pfaff, S. Toepfer, K. Zeilinger, S. Roth, D. Driesch, D. Woetzel, W. Schmidt-Heck, R. Guthke, T. Witaschek, J.C. Gerlach
Systems Analysis of the Dynamic Input/Output Behaviour of a Multi-compartment Capillary Membrane Bioreactor for High-density Liver Cell Culture.
In: Biomed Tech (2005).
Archive material
W. Schmidt-Heck, K. Zeilinger, G. Pless, J.C. Gerlach, M. Pfaff, R. Guthke
Prediction of the Performance of Human Liver Cell Bioreactors by Donor Organ Data.
In: Lect Notes Bioinformatics (2005).
doi:http://dx.doi.org/10.1007/11573067_12
K. Zeilinger, M. Pfaff, R. Guthke, W. Schmidt-Heck, S. Toepfer, D. Woetzel, D. Driesch, G. Pless, P. Neuhaus, J.C. Gerlach
Prediction of Metabolic Functions of Primary Human Liver Cells Maintained in Perfused 3D Multi-Compartment Bioreactors for Extracorporeal Liver Support.
In: Zeitschrift fuer Gastroenterologie/German Journal of Gastroenterology (2005).
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O. Reichelt, K. Junker, J. Müller, D. Driesch, G. Stein, J. Schubert
Prediction of renal allograft rejection by urinary protein analysis using seldi mass spectroscopy.
In: European Urology Supplements (2004).
doi:http://dx.doi.org/10.1016/S1569-9056(04)90009-7
C. Melle, R. Kaufmann, M. Hommann, A. Bleul, D. Driesch, G. Ernst, F. von Eggeling
Proteomic Profiling in Microdissected Hepatocellular Carcinoma Tissue using ProteinChip® Technology.
In: International Journal of Oncology (2004).
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M. Pfaff, K. Weller, D. Woetzel, R. Guthke, K. Schroeder, G. Stein, R. Pohlmeier, J. Vienken
Prediction of Cardiovaskular Risk in Hemodialysis Patients by Data Mining.
In: Methods of Information in Medicine (2004).
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M. Pfaff, D. Woetzel, K. Weller, R. Guthke, J. Vienken, G. Stein
Predictive Data Mining in Hemodialysis by Cluster and Rule Based Methods.
In: Biomedizinische Technik/Biomedical Engineering (2004).
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W. Schmidt-Heck, K. Zeilinger, M. Pfaff, S. Toepfer, D. Driesch, G. Pless, P. Neuhaus, J.C. Gerlach, R. Guthke
Network Analysis of the Kinetics of Amino Acid Metabolism in a Liver Cell Bioreactor.
In: Lecture Notes in Computer Science (2004).
doi:http://dx.doi.org/10.1007/978-3-540-30547-7_43
V. Monossov, M. Pfaff, R. Guthke
Extraction and Validation of Rule Based Knowledge from Gene Expression Data.
In: German Conference on Bioinformatics (2003).
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S. Toepfer, D. Driesch, D. Woetzel, M. Pfaff, R. Guthke
Reconstruction of Gene Regulatory Networks: A Novel Structure Optimization Method for Dynamic Models.
In: German Conference on Bioinformatics (2003).
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D. Driesch, D. Woetzel, R. Guthke, M. Pfaff
Fuzzy Cluster and Fuzzy Rule Cancer Status Prediction Based on Gene Expression Data.
In: International Workshop on Biosignal Interpretation (2002).
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M. Pfaff, R. Guthke, D. Woetzel, D. Driesch
Gene Expression Based Cancer Status Prediction for Individual Patients by an Optimized Cluster and Rule Based System.
In: EUNITE Symposium (2002).
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M. Pfaff, K. Weller, D. Woetzel, R. Guthke, K. Schroeder, G. Stein, R. Pohlmeier, J. Vienken
Prediction of Cardiovascular Risk in Hemodialysis Patients by Data Mining.
In: International Workshop on Biosignal Interpretation (2002).
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R. Berkholz, M. Pfaff, R. Guthke
Experimental Design for Bioprocess Optimization using Deterministic and Hybrid Models.
In: Biotech Journal International (2001).
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R. Guthke, W. Schmidt-Heck, R. Berkholz
Data mining based hybrid modelling and experimental design for bioprocess optimisation.
In: EUSFLAT (2001).
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R. Guthke, W. Schmidt-Heck, D. Hahn, M. Pfaff
Gene expression Data Mining for Functional Genomics.
In: Computer Appl. in Biotechnol. (2001).
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R. Guthke, W. Schmidt-Heck, R. Berkholz
Gene Expression Based Adaptive Fuzzy Control of Bioprocesses - State of the Art and Prospects.
In: Europ. Symp. on Intelligent Technologies (2001).
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D. Hahn, B. Fahnert, R. Guthke
Datenverarbeitung von 'panorama e.coli gene arrays': Hintergrunderfassung, Normalisierung, Visualisierung der Ergebnisdaten.
In: Veröffentlichung (2001).
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T. Kroll, D. Hahn, R. Guthke, S. Woelfl
Comparison of methods for background correction and standardisation.
In: Veröffentlichung (2001).
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M. Pfaff, D. Woetzel, K. Weller, K. Schroeder, R. Pohlmeier, J. Vienken, G. Stein, R. Guthke
Cluster and Rule Based Prediction in Hemodialysis: Adaptivity vs Robustness.
In: Europ. Symp. on Intelligent Technologies (2001).
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D. Woetzel, M. Pfaff, K. Weller, K. Schroeder, R. Pohlmeier, J. Vienken, G. Stein, R. Guthke
Data Mining & Prediction Tools to Support Patient Care in Hemodialysis.
In: Intelligent Systems in Patient Care (2001).
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R. Berkholz, R. Guthke, W. Schmidt-Heck, D. Roehlig
Experimental Design for Bioprocess Optimization: Numerical and Experimental Results.
In: International Biotechnology Symposium (2000).
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R. Guthke, W. Schmidt-Heck, M. Pfaff
Gene Expression Data Analysis Methods for Functional Genomics.
In: European Symposium on Intelligent Techniques (2000).
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R. Guthke, D. Hahn, B. Fahnert, T. Kroll, S. Woelfl
Gene Expression Data Mining by Fuzzy-C-Means Clustering and Fuzzy Rule Generation.
In: Veröffentlichung (2000).
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R. Guthke, B. Fahnert, D. Hahn, R. Berkholz
E.coli Gene Expression Data Mining using Fuzzy Technologies for Functional Genomics.
In: Veröffentlichung (2000).
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M. Pfaff, K. Schroeder, D. Woetzel, K. Weller, R. Guthke, R. Pohlmeier, J. Vienken, G. Stein
Dialysis Data Mining to Examine Relations between Therapy and Outcome.
In: Veröffentlichung (2000).
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R. Berkholz, R. Guthke, W. Schmidt-Heck
Sequentielle Versuchsplanung zur Optimierung von Bioprozessen mit Produktbildung im Uebergangszustand.
In: DECHEMA/GVC-Tagung (1999).
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D. Driesch, M. Pfaff, R. Guthke
Data Mining to Investigate Relations Between Seed and Main Culture Performance.
In: European Congress on Intelligent Techniques & Soft Computing (1999).
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R. Guthke, W. Schmidt-Heck, P. Mueller, H. Rodig, R. Berkholz
Data and Knowledge Based Experimental Design for Bioprocess Optimization.
In: German Conference on Bioinformatics (1999).
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R. Guthke, V. Schroeckh, R. Berkholz, M. Pfaff
Data Mining and Model based Experimental Design of Fed Batch Fermentations for Bioprocess Optimization and Functional Genomics.
In: Veröffentlichung (1999).
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R. Guthke, P. Mueller, H. Rodig, S. Lau, D. Driesch
Data Mining for Bioprocess Optimization: Applications of Wavelet Analysis and Decision Trees.
In: International Data Analysis Symposium (1999).
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R. Guthke, W. Schmidt-Heck, P. Mueller, H. Rodig, R. Berkholz
Data and Knowledge Based Experimental Design for Bioprocess Optimization.
In: European Congress on Biotechnology (1999).
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M. Pfaff, R. Guthke, R. Pohlmeier, K. Schroeder, G. Stein, J. Vienken
Using Data Mining Methods to Assess Factors Associated with Dialysis Outcome.
In: Journal of the American Society of Nephrology (1999).
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R. Guthke, M. Pfaff, F. Meyer
Optimized Fuzzy Rule Generation for Fermentation Control.
In: International Conference on Computer Applications in Biotechnology (1998).
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P. Angelov, R. Guthke, R. Berkholz
Optimal control of a fermentation process using neural networks and genetic algorithms.
In: European Congress on Intelligent Techniques & Soft Computing (1998).
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M. Pfaff, D. Driesch
Bioactivity Pattern Recognition.
In: European Congress on Intelligent Techniques & Soft Computing (1998).
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F. Meyer
Computerintegrierte Bioverfahrensentwicklung am Beispiel der dynamischen Mikrofiltration.
In: Veröffentlichung (1997).
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F. Meyer, R. Guthke, W. Knorre
Modellierung waehrend der Bioverfahrensentwicklung - ein kritischer Vergleich unterschiedlicher Modellierungstechniken.
In: Veröffentlichung (1997).
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M. Pfaff, W. Schmidt-Heck, F. Meyer, R. Guthke
Bioprocess data analysis applied to wastewater treatment.
In: Veröffentlichung (1997).
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R. Guthke, W. Schmidt-Heck, F. Meyer
Data Analysis and Knowledge Acquisition in Biotechnology.
In: Veröffentlichung (1997).
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R. Guthke, W. Schmidt-Heck, M. Pfaff
Knowledge acquisition and knowledge based control of fermentations.
In: Veröffentlichung (1997).
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